Chromosomal translocation master genes, mouse models and experimental therapeutics

Mouse Models for Chromosomal Instability

Mouse xenograft models vs GEM models for human cancer therapeutics.

Capturing novel mouse genes encoding chromosomal and other nuclear proteins.

The burgeoning wealth of gene sequences contrasts with our ignorance of gene function. One route to assigning function is by determining the sub-cellular location of proteins. We describe the identification of mouse genes encoding proteins that are confined to nuclear compartments by splicing endogeneous gene sequences to a promoterless betageo reporter, using a gene trap approach. Mouse ES (em...

A Chromosomal Translocation Causing Overproduction

The CYC7-1 mutation in the yeast Saccharomyces cereuisiae causes the production of approximately 30 times the normal amount of iso-2-cytochrome c. Genetic analysis established that the CYC7-I mutation is a reciprocal translocation involving the left arm of chromosome V and the right arm of chromosome XVZ. The chromosome V arm was broken adjacent to the gene CYC7, which determines the primary st...

In vivo models for experimental therapeutics relevant to human cancer.

The Developmental Therapeutics Program (DTP) of the National Cancer Institute (NCI) sponsored a symposium on In vivo Models for Experimental Therapeutics Relevant to Human Cancer on April 1, 2004, in Frederick, Maryland. About 50 scientists attended, with 8 invited speakers coming from Germany, the Netherlands, and various institutions in the United States. The meeting focused primarily on nove...